Wei Wang

Inference of gene regulatory networks and determination of protein specificity

The theme of our research is to infer gene regulatory networks and understand the evolutionary principles and molecular mechanisms that determine the behavior of the networks. We are interested in studying fundamental biological problems using computational algorithms that integrate information from gene expression, DNA sequence and protein-protein interaction.

A simplified sketch of such regulatory networks is shown in the figure on the right. Diverse environmental changes are detected, causing signals to be transduced through signaling pathways. Particular transcription factors are then activated and transported into nucleus to transcribe their target genes. Protein products of these genes interact with other proteins in the same or other signaling pathways to further tune responses to extracellular stimuli, thus producing a variety of feedback loops.

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